Silymarin herb reduces inflammation after liver injury from exposure to toxins

Research revealed that silymarin can reduce inflammation and liver fibrosis. This was the conclusion of researchers at the Iuliu Ha?ieganu University of Medicine and Pharmacy and the University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca in Romania after assessing the effect of silymarin on liver injuries in mice. The findings of the study were published in the Journal of Medicinal Food.

  • Silymarin is widely known for its antioxidant, anti-inflammatory, and immunomodulatory properties, and its hepatoprotective potential.
  • For the study, the researchers used carbon tetrachloride to induce liver injuries in mice.
  • The administration of carbon tetrachloride increased oxidative stress and inflammation and caused liver fibrosis.
  • After a toxic liver injury, the researchers gave mice silymarin for 10 weeks.
  • After the final silymarin treatment, the researchers measured inflammation, fibrosis, markers of hepatic stellate cell activation, and proliferative capacity.
  • The results revealed that administration of silymarin after a toxic liver injury reduced inflammation and liver fibrosis.
  • The researchers also found higher dosages of silymarin have greater benefits.

Based on the results of the study, the researchers concluded that silymarin can reduce inflammation and treat liver fibrosis.

To read more studies on natural medicines for reducing inflammation and treating liver toxicity, visit

Journal Reference:

Clichici S, Olteanu D, Filip A, Nagy A-L, Oros A, Mircea PA. BENEFICIAL EFFECTS OF SILYMARIN AFTER THE DISCONTINUATION OF CCL4-INDUCED LIVER FIBROSIS. Journal of Medicinal Food. 1 August 2016; 19(8): 789-797. DOI: 10.1089/jmf.2015.0104

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